Investigation of clinical and genetical factors influencing residual platelet reactivity after coronary stent implantation. An individualised antiplatelet strategy
témavezető: Komócsi András
helyszín (magyar oldal): PTE ÁOK Pécs, Szigeti u. 12. helyszín rövidítés: ÁOK
A kutatási téma leírása:
Dual antiplatelet therapy (AT) is essential in preventing recurrent thrombotic events after coronary interventions. However, substantial interindividual differences were described in the degree of residual platelet reactivity (RPR) despite aspirin and clopidogrel administration. High RPR is an independent predictor of death, myocardial infarction and stent thrombosis after PCI; thus, optimized AT in high-risk patients would be of great importance. We aim to establish a diagnostic system involving genetic and clinical parameters that predicts and monitors AT efficacy. With identification and better insight into the underlying mechanisms we aim to set up a tailored AT algorithm for patient with high RPR.