Nuclear magnetic resonance, due to its inherently advantageous properties, is especially suitable for noninvasive and nondestructive study of the living material (cells, tissues, intact living creatures). The method provides morphological, cellular (e.g. diffusion and perfusion) and molecular (e.g. metabolite concentrations) information practically simultaneously and in a spatially resolved manner. A further advantage of the method is that using non-radioactive isotope labelling it provides the localisation of the label not only among but also within the metabolites (i.e. which carbon atom(s) of a certain metabolite become(s) labelled). The planned studies are aimed at identifying in vivo detectable and quantifiable markers that indicate the extent and progression of the damages present in disease models. A further objective is monitoring these markers during experimental therapies (e.g. application of drug candidates) in order to characterise the efficacy of the therapy. The applicant will join the work of the MR lab in the Szentágothai Research Center of University of Pécs. The lab is already equipped with a Bruker Avance III 500 NMR spectrometer (11.7 T magnet) and during the year 2015 a 4.7 T small animal MRI instrument will be installed.
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