Corticotropin-secreting hormone (CRH) is the main brain regulator of the stress axis, playing this role primarily from the hypothalamus. Our preliminary studies suggest that CRH is produced in the brainstem, in the median raphe nucleus, and its pharmacogenetic stimulation results in increased stress hormone levels similar to the hypothalamus. Using specific mouse strains and pharmacogenetics, we aim to map the details of this regulation and its contribution to the development of anxiety-depressive disorders.
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