There are 19 Wnt genes in vertebrates coding proteins homologous to Drosophila wingless genes. Wnt-s are important in cellular proliferation, differentiation, migration and polarity. There is two main signaling pathway: the beta-catenin dependent or canonical and the beta-catenin independent or non-canonical pathways. One of the non-canonical pathways require PKC-s for signal transduction. This pathway is still poorly understood.
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