How the fetal 'allograft' avoids rejection during pregnancy remains a major unresolved immunological paradox. The complex anatomical nature of the feto-maternal interface, the involvement of multiple types of cellular immunbiological functions, as well as the wide variety of mediator cytokines, are employed in this highly adaptive, dynamically regulated system. Members of the natural immune system play a crucial role in this immunoadaptation. Here we investigate maternal gamma/delta T and NK cell populations focusing on their exact function during healthy pregnancy and on the disturbances of this precise immunoregulation.
Bejelentkezés
