Investigation of molecular mechanisms of complex neuro-immune interactions and neuroinflammation in the CNS has become a hot topic recently. The Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel expressed not only on neurones, but also on glial cells, revealed a novel neurohumoral signalling mechanism in the brain. The TRPA1 channel represents a unique type of multisteric receptors, which is activated by a broad range of endogenous inflammatory agents, such as lipid mediators, reactive oxygen species, and gasotransmitters. Its involvement is relatively well-established in certain pain and peripheral inflammatory mechanisms The pivotal role of TRPA1 receptor in the sensation of the oxidative stress and its involvement in tissue damage, degeneration and regeneration have been recently emphasised The PhD project is a comprehensive study for characterization of the roles of TRPA1 receptors in neurodegeneration, cognitive functions and neuro-inflammation with special emphasis on neuro-immune crosstalk between glial cells and neurons using an integrative approach with gene deleted mice and pharmacological tools. Methodology: multi-directional functional investigations, in vivo optical imaging, molecular biological techniques, and microscopic morphological analysis. The results will elucidate the modulatory role of TRPA1 receptors in the glia-neuron interactions during the development of neuroinflammatory-neurodegenerative disorders. It could lead to the identification of novel therapeutic targets.
felvehető hallgatók száma: 1
Jelentkezési határidő: 2023-05-17
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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