témavezető: Horváth Györgyi
társ-témavezető: Kocsis Béla
helyszín (magyar oldal): PTE ÁOK Pécs, Szigeti u. 12. helyszín rövidítés: ÁOK
A kutatási téma leírása:
Plants can produce several chemically different compounds during their metabolism. Appearance of multidrug resistant bacteria and growing antibiotic resistance is leading to a continuous need for discovering new drugs and alternative treatments against infections. The investigation of the antibacterial effect of essential oils (EOs), which are commonly used nowadays in cosmetics, health care, traditional medicine and food industry, could be one of the promising solutions for this worldwide problem. The main aims of this topic include the isolation of EOs from medicinal plant, investigation of EO composition by gas chromatography – mass spectrometry (GC-MS), determination of antimicrobial activity of EOs and their main components using agar dilution, direct bioautography and vapour phase techniques. We would like to study the effect of EOs on the outer membrane protein composition of Gram negative bacteria. Based on the in vitro results, we plant to investigate the anti-inflammatory effect of EOs in in vivo (mouse) models. The present results might open new perspectives for drug and product development purposes as well.
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