Thesis supervisor: Rita Kiss
Location of studies (in Hungarian): DE ÁOK Farmakológiai és Farmakoterápiai Intézet Abbreviation of location of studies: DEÁOK
Description of the research topic:
The prevalence of nutrition-related diseases, including metabolic and endocrine disorders, is on the rise, paralleled by an increasing incidence of infertility globally, affecting approximately 15% of couples. Female infertility presents a multifaceted aetiology, encompassing genetic predispositions, endocrine dysregulation, and reproductive organ pathologies. Notably, a substantial portion, around 30%, falls under unexplained infertility, where no discernible cause is identified. Modern lifestyle changes, such as the postponement of the first pregnancy to the 30s and 40s, changes in eating habits, stress, obesity, insulin resistance, and lack of physical activity contribute greatly to the development of female infertility.
Our research endeavors to explore the relationship between female infertility and nutrition, along with the utilization of diverse dietary supplements and plant-derived compounds. Through human clinical trials and animal model experiments, we aim to elucidate several critical inquiries: How does nutrition influence female infertility across different life stages? What impact do specific plant-based compounds have on fertility outcomes?
Our investigations encompass diverse cohorts of female patients spanning various age groups diagnosed with infertility, incorporating assessments of their nutritional and lifestyle profiles.
Augmenting our human studies, we conducted animal experiments, wherein we scrutinize the targeted effects and underlying mechanisms of action of select plant compounds and specialized diets. These animal trials involve menopausal models subjected to surgical or pharmacological ovariectomy, allowing for a deeper understanding of the nuanced interactions between nutrition, plant compounds, and reproductive health
Required language skills: angol Number of students who can be accepted: 1
Deadline for application: 2024-05-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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