Thesis supervisor: Éva Remenyik
Location of studies (in Hungarian): Department of Dermatology, Faculty of Medicine, University of Debrecen Abbreviation of location of studies: DE-BT
Description of the research topic:
Ultraviolet light is a complete carcinogen. Cumulative mutations and UV-induced immunosuppression are responsible for tumor development. Tumor formation often accompanies or precedes the increased aging of the skin, known as photoaging. UV-induced keratinocyte carcinoma (spinocellular carcinoma (SCC)) develops from actinic keratosis (AK). The number of AK and SCC patients is increasing worldwide in Caucasian populations. It is clinically difficult to assess the number of AKs on severely sun-damaged skin, to differentiate lesional and non-lesional skin areas. Therefore, field therapies (photodynamic therapy (PDT), 5-fluorouracil, imiquimod) are the most suitable for treating the entire damaged skin surface. Although the preventive effect of treatments can be inferred from clinical data, we do not know how much they can reduce the mutation load of the treated area, or how the mutation load correlates with the clinical appearance of AK and tumor formation.
Our aim is to develop a semi-invasive biopsy method to assess keratinocyte DNA mutation load on chronically sun-damaged and AK bearing skin. Through a questionnaire, we evaluate patients' sunlight exposure, objectively monitor the clinical effectiveness of field treatment, and assess mutation load molecularly. We compare the short and long-term effectiveness of different field treatments.
With this data, we contribute to a better understanding of photocarcinogenesis and the optimization of its treatment.
Required language skills: Hungarian Recommended language skills (in Hungarian): English Further requirements: Medical doctor degree
Number of students who can be accepted: 1
Deadline for application: 2024-05-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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