Thesis supervisor: Imre Biksi
Location of studies (in Hungarian): ATE Abbreviation of location of studies: ATE
Description of the research topic:
Extended-spectrum ß-lactamases (ESBLs) are enzymes found in many bacterial species, conferring resistance to most ß-lactam antibiotics. In human medicine, this significantly limits the range of agents that can be used to treat serious infections. ESBL-producing organisms usually also carry genes encoding resistance to other antimicrobials, which further limits the therapeutic options for such infections. There is a risk that strains of E. coli selected in farm animals, e.g. ESBL-producing strains, could enter the food chain and cause potentially difficult-to-treat infections in humans. In order to reduce this risk, continuous monitoring of the prevalence of ESBL-carrying bacterial strains in food producing animals is of high priority. For this purpose, E. coli strains are considered ideal as they are widely distributed in the environment, in farm animals and humans, and can cause disease in both animals and humans. Such monitoring of E. coli strains collected at slaughterhouses is ongoing under current EU regulations, but relatively little national data is available on the resistance of E. coli strains causing clinical disease. There are also few data on the general relationship between the resistance gene carriage and pathogenicity of bacterial strains in farmed animals of different ages. Modern and cost-effective molecular biological methods (e.g. whole genome sequencing) and biostatistical methods are now available for the investigation of the genetic characteristics of pathogenic bacterial strains, and we intend to use these in the planned studies.
Required language skills: angol Further requirements: DVM degree.
Specialist diploma in swine health management.
At least 2 years of working experience in a veterinary diagnostic laboratory.
Number of students who can be accepted: 1
Deadline for application: 2024-05-17
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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