ODT - THESIS TOPIC: Mihály Krisztián Józsi: Role of the factor ...


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Thesis topic proposal

Role of the factor H protein family in the complement system

THESIS TOPIC PROPOSAL

Institute: Eötvös Loránd University, Budapest
biology
Doctoral School of Biology

Thesis supervisor: Mihály Krisztián Józsi
Location of studies (in Hungarian): ELTE Department of Immunology
Abbreviation of location of studies: ELTE

Description of the research topic:

The proper action of the complement system ensures its physiological functions without damaging the host. Factor H is of the complement regulators; in addition, in humans five factor H-related (FHR) proteins exist that show a high degree of structural similarity to each other and to factor H. Gene variants of both factor H and the FHRs have been linked to various complement-mediated diseases, such as age-related macular degeneration and certain kidney diseases. Unlike factor H, the role of the FHR proteins is largely unknown. The PhD candidate is expected to functionally characterize the human FHRs, their role in complement activation and regulation, their interactions with various host and non-host derived ligands, such as pentraxins and microbial proteins, and their effect on factor H function.

Required language skills: English
Further requirements:
independent thinking, proactive approach, excellent laboratory (manual) skills

Number of students who can be accepted: 1

Deadline for application: 2024-05-31

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).