Thesis supervisor: Imre Derényi
co-supervisor: Róbert Horváth
Location of studies (in Hungarian): HUN-REN Nanobiosensorics Laboratory Abbreviation of location of studies: ELTE
Description of the research topic:
Today's increasingly popular biophysical research methods involve label-free optical biosensors and cell manipulation techniques. These procedures allow real-time data recording of the studied biological system without the use of labeling molecules, with high sensitivity even at the molecular scale. They enable the analysis of multiple samples simultaneously in a relatively short time, making them cost-effective and eliminating the disruptive effects of labeling molecules. The topic aims to explore interactions between various molecules with previously unknown kinetic characteristics and examine how these molecules affect cell adhesion and proliferation capacities, all using modern biophysical techniques such as FluidFM, microscopic techniques, and specialized optical biosensors focused on individual cells. These methods are becoming increasingly crucial in basic biophysical research, drug research, material sciences, and industry. Understanding cell adhesion kinetics is particularly important in oncology, immunology, and neuroscience, and relevant studies may contribute to developing novel drug candidates. The doctoral thesis aims to study adhesive processes using the aforementioned technologies, designing and executing measurements, and establishing optical and biophysical models that lead to a deeper understanding of cell adhesion behavior and a more precise characterization of cell-matrix interactions. Such methods include fluorescent labeling of integrins combined with FluidFM-based cell manipulation or examining trajectories of microscopic beads placed in gels serving as cell adhesive surfaces. The scientific activity within the framework of the thesis proposal includes experimental design, execution, data evaluation, statistical analysis, biophysical modeling, and presentation of results in scientific journals and conferences. The experimental research required to obtain the doctoral degree will be conducted at the HUN-REN EK MFA Nanobiosensorics Laboratory in Budapest, involving collaboration with numerous domestic and international partners.
Required language skills: English Further requirements: MSc in physics or biophysics
Number of students who can be accepted: 1
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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