Thesis supervisor: László Homolya
Location of studies (in Hungarian): HUN-REN Research Centre for Natural Sciences Abbreviation of location of studies: H-REN
Description of the research topic:
In this program, we aim at identifying the molecular and cellular factors that confine and modulate development and differentiation of human stem cell-derived neural progenitor cells (NPCs) with special focus on cell polarity development. We primarily investigate the molecular details of microglia and NPC interaction, whether cell-cell communication is based on humoral factors or involves extracellular vesicles; whether cell to cell contact plays a role in this process; whether this communication is unidirectional or mutual, what the identity of the signal substances is, etc. The applied methods include advanced cell culturing, e.g., 3D or organoid culturing, basic biochemical techniques, immunofluorescence staining, and advanced microscopy, such as confocal microscopy and high content screening. The program is not only interesting from a basic science aspect but also holds the potential for practical utilization. Deeper understanding of human neural development and regeneration at the progenitor level may provide opportunities for development of novel regenerative therapeutic interventions.
Required language skills: English Further requirements: Basic knowledge in biochemistry and molecular biology. M.Sc. degree in a biology-related academic discipline (biologist, bioengineer, physician, pharmacist, biotechnologist, etc.) Experience in microscopy techniques is an advantage.
Number of students who can be accepted: 2
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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