Thesis supervisor: Gábor Zoltán Boross
Location of studies (in Hungarian): Institute of Evolution, Centre for Ecological Research, HUN-REN Hungarian Research Network Abbreviation of location of studies: H-REN
Description of the research topic:
Cancer has been recognized as an evolutionary process since Nowell’s 1976 seminal paper. Evolutionary biology changed only in the last few decades from a mainly theoretical and observational science to an experimental field. Most studies have been conducted on microbes in well-mixed liquid media, corresponding to the “planktonic ideal”, where each individual directly competes with all other individuals. However, the majority of cancers form solid tumors, where somatic evolution of cells happens in a spatially confined manner in a highly complex environment that can substantially influence population dynamics.We need to better understand these clonal dynamics to create models on how intra-tumor genetic heterogeneity is created and maintained in human tumors, resulting in resistance to therapy or cancer recurrence.
Required language skills: English Further requirements: We are looking for candidates with M.Sc. degrees in biology, physics, mathematics, computer science or similar to join our recently founded group to do wet and/or dry lab work in the intersection of evolutionary and cancer biology.
Number of students who can be accepted: 3
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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