Thesis supervisor: Csaba Vágvölgyi
co-supervisor: Miklós Takó
Location of studies (in Hungarian): Department of Microbiology, Faculty of Science and Informatics, University of Szeged Abbreviation of location of studies: SZTE
Description of the research topic:
Microbial enzymes (e.g., cellulases, ligninases, lipases, proteases, chitinases) find promising applications in a wide range of industrial processes; however, development of biotechnological methods appropriate for environmental and food-industrial expectations requires identification of novel biocatalysts/producing isolates. These studies extend to characterization of producing parameters as well as biochemical properties of the new enzymes. Proper analysis of the enzymes involves high-yield fermentation and purification as well. During this program, we analyze the production of microbial enzymes (especially from filamentous fungi) on plant-derived waste materials. Besides identification and characterization of new enzyme producing isolates/enzymes, we study the possibilities and biological requirements of the applicability of isolates, which have been found to have significant enzyme production and fermentation properties. This program also extends to practical utilization of produced microbial enzymes as well as preparatory studies for their heterologous expression.
Our relevant publications:
1. Volford B, Varga M, Szekeres A, Kotogán A, Nagy G, Vágvölgyi C, Papp T, Takó M: β-Galactosidase-producing isolates in Mucoromycota: screening, enzyme production, and applications for functional oligosaccharide synthesis. Journal of Fungi 7:(3) 229. (2021)
2. Kotogán A, Zambrano C, Kecskeméti A, Varga M, Szekeres A, Papp T, Vágvölgyi C, Takó M: An organic solvent-tolerant lipase with both hydrolytic and synthetic activities from the oleaginous fungus Mortierella echinosphaera. International Journal of Molecular Sciences 19:(4) 1129. (2018)
3. Takó M, Kotogán A, Papp T, Kadaikunnan S, Alharbi NS, Vágvölgyi Cs: Purification and properties of extracellular lipases with transesterification activity and 1,3-regioselectivity from Rhizomucor miehei and Rhizopus oryzae. Journal of Microbiology and Biotechnology 27:(2) pp. 277-288. (2017)
4. Takó M, Kotogán A, Krisch J, Vágvölgyi Cs, Mondal KC, Papp T: Enhanced production of industrial enzymes in Mucoromycotina fungi during solid-state fermentation of agricultural wastes/by-products. Acta Biologica Hungarica 66:(3) pp. 348-360. (2015)
Required language skills: English Further requirements: MSc diploma from relevant fields (e.g. Biology, Food engineering, Biotechnology)
Number of students who can be accepted: 2
Deadline for application: 2024-08-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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