Thesis supervisor: Áron Szabó
Location of studies (in Hungarian): HUN-REN Biological Research Center, Szeged, Institute of Genetics Abbreviation of location of studies: SZBK
Description of the research topic:
Glia support neuronal function in various ways and there is ample crosstalk between the two cell types that can influence the fate and survival of either partner. We are interested in membrane trafficking pathways in glia, especially phagocytosis, early damage signalling and their involvement in neuronal death, axon degeneration and regeneration. We also study how neuroinflammation is fuelled by glial immunity leading to demise of neurons and the role of purinergic pathways in neuron-glia signalling. We use Drosophila as a versatile and genetically tractable model that offers unsurpassed access to cell types and their genetic manipulation in the nervous system. Simple injury paradigms such as wing transection for the peripheral tissues and antennal ablation or traumatic brain injury for the CNS are used to inflict reproducible injuries. A combination of advanced genetics, fluorescence and electron microscopy, cell type-specific proteomics/ transcriptomics and behavioural tests is applied to tackle the questions arising from the investigation of the above-mentioned topics.
Required language skills: English Number of students who can be accepted: 4
Deadline for application: 2024-08-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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