Thesis supervisor: János Barna
Location of studies (in Hungarian): ELTE TTK, Department of Genetics Abbreviation of location of studies: ELTE
Description of the research topic:
Protein damage caused by various environmental stresses induces distinct cell protective mechanisms, such as the heat shock response. During heat shock response HSF1 (heat shock transcription factor 1) helps to refold or degrade damaged proteins via activation of chaperone gene expression. Most HSF-1 target genes identified so far encode for heat shock proteins (HSPs). However, during the last decade HSF-1 has been implicated in fundamental physiological and pathological processes that expand beyond heat shock response. HSF-1 has been shown to influence cell growth and metabolism, development, aging, and immunity as well as carcinogenesis and tumor progression.
The aim of the project is the in vitro and in vivo identification and characterization of novel HSF-1 target genes and uncovering the central role of HSF-1 in the coordination of cellular stress response pathways in C. elegans and human cell lines. We also aim to identify novel interactors of HSF-1 that mediate novel roles of HSF-1. Our results may provide new insight into how HSF-1 and distinct cellular stress responses interact during development, aging and in age related pathologies.
Required language skills: English Further requirements: expertise in the model systems C. elegans, molecular biology, and genetic analysis, motivation
Number of students who can be accepted: 1
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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