Thesis supervisor: János Barna
Location of studies (in Hungarian): ELTE Faculty of Science Department of Genetics, ELTE TTK, Doctoral School of Biology Abbreviation of location of studies: ELTE
Description of the research topic:
Protein damage caused by various environmental stresses induces distinct cell protective mechanisms, such as the heat shock response. During heat shock response HSF1 (heat shock transcription factor 1) helps to refold or degrade damaged proteins via activation of chaperone gene expression. Most HSF1 target genes identified so far encode for heat shock proteins (HSPs). However, during the last decade HSF1 has been implicated in fundamental physiological and pathological processes that expand beyond the heat shock response. It has been shown that HSF1 can play roles in cell growth, development, aging, and immunity as well as in carcinogenesis and tumor progression.
The aim of the project is the identification of novel HSF-1 interactor proteins that modulate its activity, making it possible to regulate transcription in a cell- or tissue-specific manner. Genetic and bioinformatic analyses of these interactors may provide new insight into the role of HSF-1 during development, aging and in age related diseases.
Required language skills: English Further requirements: Motivation is a must. Expertise in methods of molecular biology and/or in genetic analysis is a must. Expertise in bioinformatics is an advantage. Expertise in Python or R is an advantage.
Number of students who can be accepted: 2
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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