Thesis supervisor: Balázs Pál
Location of studies (in Hungarian): Department of Physiology, Faculty of Medicine, University of Debrecen Abbreviation of location of studies: Élett
Description of the research topic:
Astrocytes contribute to the brain homeostasis in several ways including glutamate clearance and the glymphatic system. These astrocytic functions have been shown to decline with age which might alter their contribution to the pathophysiology of ischemic lesions, hemorrhage, vascular and cytotoxic edema. In this project, we plan to perform in vitro experiments on murine and human neocortical and hippocampal brain slice preparations from different age ranges. In vitro models of ischemia, hemorrhage and edema will be set and evaluated with various methods as patch clamp, calcium imaging, morphological analysis and immunohistohemistry. In certain cases, samples from patients suffering from ischemic brain lesions or hemorrhage will be analysed as well. As an outcome of the study, we will be able to assess the pathophysiological significance of differences in aging of the human and murine astrocytes.
Required language skills: English Number of students who can be accepted: 1
Deadline for application: 2024-05-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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