Thesis supervisor: Attila Kiss
Location of studies (in Hungarian): University of Debrecen, Faculty of Agriculture and Food Science and Environmental Management (138. Böszörményi street, 4032 Debrecen) Abbreviation of location of studies: A/53
Description of the research topic:
Our goal is to have a biochemical model system available that enables the assessment of the digestive and physiological effects of different feed components, bioactive active ingredients and nutrients, the comparative evaluation of bioavailability, and the determination of the degree of utilization, with particular regard to protein maintenance and immune-boosting functions, on antioxidants, micronutrients and gut microbiota.
In the course of our work, we develop an automated in vitro digestion model based on the parallel examination of samples supported physico-chemical processes and optimized for the digestive characteristics of humans and monogastric farm animals.
A sequential, four-step (mouth, stomach, small intestine and large intestine) digestive model system capable of simulating the entire human and pig gastrointestinal system will be created using 16 enzymes and cofactors.
Factors capable of positively influencing the composition of the intestinal microbiota are studied using culture and molecular biological methods, thus opening up a way to compare the functioning of the human and pig intestinal microbiota systems, and to develop a system based on tissue culture that simulates the processes of absorption.
In summary, we are building a complex in vitro digestion model system that is suitable for evaluating the biological utilization, stability and actual physiological activity of individual components, active ingredients and products.
Required language skills: English (advanced mid) Further requirements: proactivity
high level of problem solving and communication skills
independent, precise work
teamwork
Number of students who can be accepted: 1
Deadline for application: 2025-01-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
Login
