Thesis supervisor: Hajnalka Lőrincz
Location of studies (in Hungarian): Debreceni Egyetem, Általános Orvostudományi Kar, Belgyógyászati Intézet Abbreviation of location of studies: DE-BI
Description of the research topic:
The aging society and obesity have been shown a growing public health problem in Hungary;
therefore, the investigation of gerontological subjects are extensively become the focus of the
research attention. Sarcopenia is defined as the progressive and generalized loss of skeletal
muscle mass and strength which also means the co-existence of low muscle mass and strength
and the high body fat content. From the fifth decade, the bone density decreases by about
1–1.5 percent per year, muscle mass by about 1.5–2 percent per year, and the muscle strength
by about 2.5–3 percent per year; while the body fat content shows a continuous increase due
to obesity. The intramuscular fat deposition leads to significant change in the circulating
levels of skeletal muscle secreted myokines and white adipose tissue secreted adipokines.
Low-grade inflammation, impaired mitochondrial β-oxidation, enhanced lipid peroxidation,
increased oxidative stress and insulin resistance are associated with the progression of
sarcopenic obesity, which increases the risk of adverse outcome and causes higher mortality
in elderly. Appropriate nutrition for the elderly, extensive dietary counselling, active lifestyle,
questionnaire surveys and monitoring changes in body composition are essential to protect the
quality of life of elderly. The aim is this study to investigate inflammatory processes,
oxidative stress and the markers of myokine/adipokine profile in elderly subjects with
sarcopenic obesity.
Required language skills: English Further requirements: Dietetics BSc, specialized MSc, experience in care for the elderly, experience in molecular biology
Number of students who can be accepted: 1
Deadline for application: 2024-05-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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