Thesis supervisor: Béla Kajtár
Location of studies (in Hungarian): PTE ÁOK Abbreviation of location of studies: ÁOK
Description of the research topic:
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia. Disease-specific translocations typical of other leukemias are not characteristic in CLL, it is a genetically heterogeneous disease. CLL is a systemic disease, detected genetic alterations are commonly subclonal. Mutation status of the rearranged IGH gene, TP53 mutations and deletions are important prognostic as well as predictive factors, however, in a subset of cases, more than one clonal IGH gene rearrangement or subclonal TP53 mutation is detectable. Our aim is to investigate patterns of IGH gene rearrangments in biclonal CLL cases and determine their prognostic significance. We will determine clonal relationships between different genetic aberrations in case of their simultaneous appearance in CLL cases. We will also assess a cheap, potential screening method to detect TP53 mutation in CLL samples.
Number of students who can be accepted: 1
Deadline for application: 2024-05-16
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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