Thesis supervisor: Diána Simon
co-supervisor: Katalin Böröcz
Location of studies (in Hungarian): PTE ÁOK Abbreviation of location of studies: ÁOK
Description of the research topic:
Contradictory reports are available on vaccine-associated hyperstimulation of the immune system, provoking the formation of pathological autoantibodies. Despite being interconnected within the same network, the role of the quieter, yet important non-pathological and natural autoantibodies (nAAbs) is less defined. NAAbs have been described to have a number of functions in the immune system, including removal of apoptotic debris, acceleration of primary immune responses, suppression of autoimmune and inflammatory responses, regulation of B-cell responses and B-cell development. By inhibiting the targeted response against their own antigens, they play an important role in maintaining tolerance, protecting against the development of pathological autoimmune responses. In contemporary literature, an increasing number of communications are addressing the apparent controversy regarding the inducible versatility of the supposedly stabile and evolutionary conserved nAAb pool. The effects of vaccinations and infections may also play an important role in the dynamic changes in the natural autoantibody network. We hypothesize that with a competent antigenic trigger, nAAbs may also display a moderate level of dynamic adaptability, detectable at the level of antibody titers. Thus, the topic is mainly focused on the investigation of the possible connections between natural autoantibodies, pathological autoimmune disease-associated autoantibodies and vaccine- or infection-induced antibodies.
Number of students who can be accepted: 1
Deadline for application: 2024-05-16
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
Login
