Thesis supervisor: Tímea Berki
co-supervisor: Diána Simon
Location of studies (in Hungarian): PTe ÁOK Abbreviation of location of studies: ÁOK
Description of the research topic:
The rate of female infertility is increasing in all developed countries. Female fertility can be affected by diseases or dysfunctions of the reproductive tract, neuroendocrine system, and immune system. Reproductive autoimmune failure can be associated with a general over activation of the immune system or with immune system reactions specifically directed against ovarian antigens. Dysregulation of the immune system with increased production of autoantibodies remains a putative etiologic candidate for unexplained infertility. Natural autoantibodies together with the regulatory T and B cells are components of the tolerance induction. Natural autoantibodies are secreted by B1 cells without prior antigen stimulation against evolutionary conserved molecules and bind various ligands with relatively low affinity. Since natural IgM autoantibodies serve as first line of defense against infections and false apoptotic cells with their polyreactive nature, they might be protective during fertilization, implantation and serve as a tolerance keeping buffer during normal pregnancy. They can protect the embryo from the attacking maternal immune response. We expect higher protective natural IgM level in normal pregnancy and higher IgG natural and pathological autoantibody levels in mothers with pathological pregnancies.
Previous studies showed that IgM natural anti-topoisomerase I-F4 fragment and anti-citrate synthase autoantibody levels are part of the natural immune repertoire with beneficial roles in autoimmune diseases. Parallel to pathological autoantibodies (AAb) related to systemic and organ specific autoimmune diseases we will measure natural IgM and IgG autoantibodies in sera of patients with unidentified infertility and pregnant women with different autoimmune diseases in the 1st, 2nd and 3rd semester. Commercial and in-house ELISA tests will be used for autoantibody measurements.
Number of students who can be accepted: 1
Deadline for application: 2024-05-16
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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