Thesis supervisor: Krisztián Kvell
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Extracellular vesicles are cell-derived lipid bilayer-enclosed structures. Acute endurance exercise promotes dynamic secretion of exosomes (20-140 nm) and microvesicles (100-1000 nm) from skeletal muscle. The increase in extracellular vesicle abundance is intensity-dependent. Exercise-induced release of peptides and nucleic acids from skeletal muscle also termed ‘exerkines’ has an important role in mediating systemic adaptation. We propose that many of the exerkines travel within extracellular vesicles, because the extracellular milieu is probably not a suitable environment for exposed labile exerkines.
The aim of our research is to evaluate the effects of exercise on saliva, blood, urine release of microvesicles and exosomes. Compare and characterize the cargo contents of exosomes and microvesicles with high-throughput methods.
The ultimate goal of this research is to greater understand the role of exerkines in physiological adaptations mechanisms and individual exercise responses.
Number of students who can be accepted: 1
Deadline for application: 2024-05-16
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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