ODT - THESIS TOPIC: Endre Pál: Investigation of mitochondrial alterations ...


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Thesis topic proposal

Investigation of mitochondrial alterations in muscle diseases

THESIS TOPIC PROPOSAL

Institute: University of Pécs
clinical medicine
Doctoral School of Clinical Neurosciences

Thesis supervisor: Endre Pál
Location of studies (in Hungarian): PTE ÁOK, Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Beyond the primary mitochondrial diseases there are several muscle diseases and neurodegenerative diseases, whre mitochondrial damage was detected (decreased enzime activity, presence of abnormal mitochondria in tissues, mitochondrial DNA deletions). The puropes of this study to detect these alterations in different myopathies: quantification of mitochondrial pathology in autoimmune myositis (measuring enzyme activity, finding ragged red fibers /RRF/ and cytochome-c oxidase /COX/ negative fibers, long-range PCR). Same investigations is planned to be performed in muscle dystrophies and if possible in acquired myopathies pl. statin myopathy, ischemic muscle damage. We test mitochondrial biomarkers suitable for monitor the diseases (eg. FGF21).

Number of students who can be accepted: 1

Deadline for application: 2024-05-16

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).