ODT - THESIS TOPIC: György ifj. Sétáló: Studying the differentiation and ...


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Thesis topic proposal

Studying the differentiation and apoptosis of rat pheochromocytoma (PC12) cells

THESIS TOPIC PROPOSAL

Institute: University of Pécs
theoretical medicine
Doctoral School of Interdisciplinary Medical Sciences

Thesis supervisor: György ifj. Sétáló
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Rat pheochromocytoma (PC12) cells don't require the presence of nerve growth factor (NGF) for their survival. Upon treatment with the peptide, however, they differentiate into a sympathetic neuron-like phenotype. The main transducer of the underlying signals is the extracellular signal-regulated kinase cascade. In the complete absence of trophic support the cells die by apoptosis. Our goal is a better characterization of these signaling processes. Our experiments are carried out using immunoblots and confocal laser scanning fluorescence microscopy.

Number of students who can be accepted: 1

Deadline for application: 2024-05-16

2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).