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Thesis topic proposal
 
Péter Hegyi
ELEFANT study

THESIS TOPIC PROPOSAL

Institute: University of Pécs
theoretical medicine
Doctoral School of Pharmacologycal and Pharmaceutical Sciences

Thesis supervisor: Péter Hegyi
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK


Description of the research topic:

Acute pancreatitis (AP) is a life-threatening inflammatory disease. Of the various etiological factors, hypertriglyceridemia (HTG-AP) causes the most severe inflammation of the pancreas with the highest mortality rate. Its frequency is constantly increasing due to changes in eating habits and the obesity epidemics worldwide.
ELEFANT is a randomized, controlled, multicentric, international study designed to investigate the effectiveness of early triglyceride lowering and to select the appropriate intervention in patients with HTG-APs. The trial is testing the concept that early elimination of triglycerides (TG) and free-fatty acids from the blood is beneficial in HTG-AP.
Patients between the ages of 18-80 with HTG-AP defined by TG level over 11.3 mmol/l (1000 mg/dL) and with an abdominal pain less than 48 h prior admission are included. On admission, after laboratory and imaging examinations if the patients agree to the study, they are randomized into three groups: (1) patients who undergo plasmapheresis, (2) patients who receive insulin and heparin treatment and (3) patients with no additional specific treatment.

Number of students who can be accepted: 1

Deadline for application: 2024-05-16


2024. IV. 17.
ODT ülés
Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).

 
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