Thesis supervisor: Kata Horváti
Location of studies (in Hungarian): Research Centre for Natural Sciences, "Momentum" Peptide-Based Vaccines Research Group Abbreviation of location of studies: H-REN
Description of the research topic:
"Research and development of vaccines against a variety of infectious diseases, where the causative agent shows high antigenic diversity due to fast mutation rate or metamorphosis across variation of stages, are still challenging. Therefore, immunization with combination of antigens derived from all stages of the parasite’s life cycle has crucial benefits. Multiple epitope containing polyvalent vaccines can induce a more effective and universal immune response. The emergence and spread of respiratory infections caused by drug-resistant or even multiresistant bacteria calls for the development of novel, innovative intervention measures. Therapeutic vaccination would provide an attractive alternative strategy to fight against these “superbugs”.
In this project, epitopes derived from immunodominant proteins expressed during the different stages of bacteria, associated with respiratory infection, will be synthesized by using state-of-the-art conjugation techniques. The main goal is to develop new formulation and adjuvant techniques which can significantly enhance the efficacy of synthetic subunit vaccines. Novel constructs will be tested in in vitro and in vivo functional assays and the immunstimulatory effect will be determined."
Required language skills: English Further requirements: laboratory practice in organic chemistry
Number of students who can be accepted: 2
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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