Thesis supervisor: Adél Sepsi
co-supervisor: Csaba Éva
Location of studies (in Hungarian): HUN-REN Centre for Agricultural Research (HUN-REN CAR) Abbreviation of location of studies: E-REN
Description of the research topic:
Meiosis is the specialised cell division that gives rise to the fertile gametes. In early meiosis (prophase I) homologous chromosomes pair and exchange parts of their genetic information via crossing overs during the process of meiotic recombination. Recombination is key to genetic diversity and sexual reproduction as defects in crossing over formation lead to incorrect chromosome segregation, loss of genetic information and infertility. How homologous chromosomes recognise each other, pair, and recombine in the meiotic cell nucleus is still a widely researched question. The present project aims to investigate the role of chromatin dynamics in the recognition of homologous chromosomes and meiotic recombination in cereals. We build on our earlier findings showing that early stages of recombination and chromosome pairing are accompanied by a characteristic centromere activity at the nuclear periphery, near the nuclear envelope. We will use reverse genetics supported by CRISPR Cas gene editing, molecular cytology, and high-resolution microscopy in barley (Hordeum vulgare L) to reveal key determinants of chromatin dynamics and investigate their role in homologous chromosome recognition and recombination.
Required language skills: English Number of students who can be accepted: 1
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
Login
