Thesis supervisor: Gergely Róna
Location of studies (in Hungarian): Institute of Enzymology, HUN-REN Research Centre for Natural Sciences Abbreviation of location of studies: H-REN
Description of the research topic:
Neurological disorders are one of the leading cause of disability and death worldwide. The fundamental goal of this proposal is to obtain a better understanding of defects in neuronal DNA repair, and to exploit this knowledge to identify new vulnerabilities in neurodegeneration. The nervous system is highly susceptible to all forms of stress, including DNA damage, due to its large energy requirements, high transcriptional activity, and the long lifespan of these cells. Data suggests that mutations in DNA repair genes are associated with several neurological abnormalities and defects in DNA repair are responsible for somatic tri/dinucleotide expansions, such as Huntington’s disease (HD), or Amyotrophic lateral sclerosis (ALS). Neurons can repair and protect their genome against DNA damage under physiological conditions despite lacking DNA replication, which limits their opportunity for DNA repair. What remains in question, however, are the underlying molecular mechanisms behind these repair processes and how these non-renewable cells maintain their genomic integrity over many decades of life.
Required language skills: English Further requirements: biologus, biomernok, vegyesz mesterszakos oklevel
Jo angol nyelvismeret (iras, olvasas, beszed).
Number of students who can be accepted: 1
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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