Thesis supervisor: Péter Gál
co-supervisor: József Dobó
Location of studies (in Hungarian): Research Centre for Natural Sciences, Institute of Enzymology Abbreviation of location of studies: H-REN
Description of the research topic:
Innate immunity forms the first lines of defense against pathogenic microorganisms, and launches an immediate and efficient reaction upon the appearance of danger signals. The complement system is a major effector component of the innate immune system consisting of about 40 protein components. The complement system can recognize, label and destroy pathogens and altered host-cells (e.g. apoptotic, necrotic cells, and cancer cells). The major components of the complement system are serine protease enzymes, which activate each-other in a cascade-like manner. The complement system is evolutionary end functionally closely related to the other protease cascade systems in the blood (e.g. the blood coagulation, the fibrinolysis, and the contact systems). In our research group we study the mechanism of the complement activation by using biochemical, biophysical and molecular biological methods. We recombinantly express complement proteins and their fragments, and characterize them from structural and functional point of view. We make specific inhibitors against the complement proteases using structural information and combine them with in vitro evolution techniques. Another major research goal is to reveal the hitherto unknown, non-canonical functions of complement proteins (e.g. interaction with cell-surface receptors, tumorigenesis, and embryonic development). To clarify the physiological role of the complement system we plan to use animal models. We also study the regulation mechanisms of the system and the cross-talks with other cascade systems. The actual research plan will be finalized after the consultation with the applicant.
Required language skills: English, Hungarian Further requirements: diploma in chemistry, or biology, or bioengineer, or medical doctor, or pharmacist; experience in laboratory work is an advantage
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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