Thesis supervisor: Magdolna Szántó
Location of studies (in Hungarian): University of Debrecen, Faculty of Medicine, Department of Medical Chemistry Abbreviation of location of studies: DEOVI
Description of the research topic:
ADP-ribosylation is a post-translational protein modification involved in the regulation of various biological processes, including DNA repair, transcription and translation, cellular metabolism and energy balance, lipid synthesis, cell differentiation, immune response and inflammation.
The ADP-ribosylating enzymes (also known as PARPs) are of particular importance from a pharmacological point of view, as several PARP inhibitors have been approved for clinical use by the Food and Drug Administration (FDA) in recent years. Their primary indication is the therapy of ovarian and breast cancer. However, since numerous in vivo and in vitro studies demonstrated that the inhibition of PARP activity can hinder the activation of inflammatory pathways, the application of PARP inhibitors in anti-inflammatory indications has been raised, but there is still little preclinical data available.
We have already shown in gene knockout animal models that the dysregulation of PARP enzymes may play a role in such pathological processes affecting skin keratinocytes that are relevant in the pathomechanism of psoriasis. In chronic skin inflammatory diseases, however, the immune cells infiltrating the skin also play an important role. Since PARPs are involved in the differentiation of certain cells of both innate and acquired immunity, we hypothesize that PARPs also have immunopathological significance in the development of inflammatory skin diseases such as psoriasis or atopic dermatitis.
In our current research plan, using in vivo and in vitro inflammatory models, we aim to characterize the effects of clinically applied PARP inhibitors on the activation and differentiation of resident and infiltrating immune cells of the skin.
Required language skills: angol középfokú nyelvtudás Number of students who can be accepted: 1
Deadline for application: 2024-05-15
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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