Thesis supervisor: Péter Géza Hausinger
Location of studies (in Hungarian): SZTE Belgyógyászati Klinika, Invazív Kardiológiai Részleg Abbreviation of location of studies: SZAKK
Description of the research topic:
Research description:
The research topic focuses on human vascular system disorders and their treatment.
On one hand, this involves in vitro (monolayer and 3D cell cultures; explant and/or co-cultures) and in vivo (performed on Wistar rats) research using experimental models by which the relationship between environmental factors and their effects is investigated at mechanism level in order to explore potential vascular disrupting events. During experimental research, the direct vascular effects of compounds with endocrine-, neuroendocrine and homeostatic disruptor properties are studied on the dominant systemic cycles of endothelial and smooth muscle cells researching their potential pathoetiological role in the development of vascular system disorders.
On the other hand, the research carried out in medical practice concentrates on discovering the background mechanisms that determine the functional significance of cerebrovascular morphological alterations. During human studies, the cerebrovascular adaptation of the methods routinely used for the invasive functional assessment of the cardiovascular system and the comparative analysis with the cardiovascular system are aimed. Furthermore, systematic study of the safety and effectivity of alternative arterial access sites (e.g. temporal superficial artery) that can potentially be used for endovascular interventions is planned.
References:
1. Nagyeri G, Valkusz Z, Radacs M, Ocsko T, Hausinger P, Laszlo M, Laszlo FA, Juhasz A, Julesz J, Galfi M. Behavioral and endocrine effects of chronic exposure to low doses of chlorobenzenes in Wistar rats. Neurotoxicol Teratol. 2012 Jan-Feb;34(1):9-19
2. Molnár Z, Pálföldi R, László A, Radács M, Sepp K, Hausinger P, Tiszlavicz L, Valkusz Z, Gálfi M. Effects of chronic and subtoxic chlorobenzenes on adrenocorticotrophic hormone release. J Environ Sci (China) 2015 Aug 1;34:165-70
3. NH. Pijls, B. de Bruyne, K. Peels, PH. van der Voort, HJ. Bonnier, JJ. Bartunek, et al.: Measurement of fractional flow reserve to assess the functional severity of coronary-artery stenoses. N Engl J Med. 1996; 334(26): 1703-1708
4. J. Chen: A feasibility study of fractional flow reserve assessment for carotid artery stenosis interventional therapy. Chin J Cerebrovasc Dis;
Required language skills: english Further requirements: TDK munka
Number of students who can be accepted: 3
Deadline for application: 2024-04-30
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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