Thesis supervisor: Lajos Vince Kemény
Location of studies (in Hungarian): SE Abbreviation of location of studies: SE
Description of the research topic:
The overall goal of this PhD project is to identify novel therapeutic targets in melanoma and to assess currently utilized side effect profiles and the efficacy of immune-checkpoint blockade therapies.
During the project, the PhD student will perform genome-wide crispr screens in various human melanoma models in order to identify specific regulators of ferroptotic cell death. After identifying genes associated with either resistance to ferroptosis or genes sensitizing to ferroptotic cell death, the PhD student will evaluate the pathways responsible for the regulation of ferroptosis using bioinformatic tools. Based on the results of the screening, the student will validate the top targets and examine the exact function of the new targets using various biochemical and cellular assays. The relevance of identified genes for melanoma progression, survival and clinical benefit of immune checkpoint blockade is evaluated by analyzing transcriptomic and clinical data of melanoma samples obtained from patients.
During the clinical side of the project, the student is expected to conduct literature research on current therapies of melanoma and to perform meta-analyses to describe the current efficacy and side effect profile of the immune-checkpoint based therapies.
During the program, students are expected to acquire and develop strong cell biological, molecular biological and bioinformatic skills, as well as presentation and communication skills. Due to the multidisciplinary nature of the project, strong collaboration skills are also expected to develop.
The project can be tailored to the interests and individual goals of the prospective doctoral student upon discussion and mutual agreement.
Number of students who can be accepted: 3
Deadline for application: 2024-05-31
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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