Thesis supervisor: Erzsébet Pásztiné Gere
Location of studies (in Hungarian): https://univet.hu/hu/ Abbreviation of location of studies: ATE
Description of the research topic:
Due to the co-occurence of mycotoxins in feeds, determination of their combined toxicological effects such as hepatic and intestinal damage is of key importance. IPEC-J2 cell line as intestinal epithelial cell model and primary hepatocytes will be used in our experiments for examination of interaction among intestinal epithelium/liver and mycotoxins. In the frame of this PhD project special emphasis will be placed on (i) study on the cytotoxic effects of mycotoxins on hepatocytes and on enterocytes after acute and chronic exposure and (ii) determination of changes in activities for CYP isoenzymes after addition of mycotoxin combinations (iii) searching for potential beneficial properties of probiotics and their metabolites, antioxidants in the prevention of mycotoxin combination- induced cell damage.
The experiments will include analysis of cell cytotoxicity and intracellular/extracellular reactive oxygen species in addition to activity measurements of different CYP isoenzymes to characterize the effects of combined mycotoxins and to establish reliable and precise method for prediction of drug bioavailability after mycotoxin contaminations.
Required language skills: angol Further requirements: 1. diploma of veterinary medicine, Pharm D or biologist (MSc)
2. English language knowledge (min. B2 level)
3. experience in research work
4. problem solving and computational skills
5. strong commitment for research
Deadline for application: 2023-05-19
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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