Thesis topic proposal
Evaluation of prognostic factors in the surgical treatment of colorectal liver metastases


Institute: University of Pécs
clinical medicine
Doctoral School of Clinical Medicine

Thesis supervisor: András Papp
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Colorectal cancer (CRC) are on the second place in cancer related death in Hungary. It means about 8500 new cases annually, with an estimated 5000 annual death. About 50 % of the CRC patients have liver metastases during their life and mostly it is the cause of death. Also well known that only 25 % of colorectal liver metastases (CRLM) are primary resectable, and about 20% would be resectable with the help of oncological treatment. Our aim is to analyse the previously clinical data to clear what kind of prognostic factors have role in the survival after a successful hepatic resection of CRLM. We would like to find a clinically useable factor, which is able to predict the prognosis, especially to clear the usability of the „heat-shock proteins” (HSP), which were earlier established as a good prognostic factor in other malignancies. In addition we would like to evaluate the correlation between the oncological quality of the surgical resection and the survival, especially at R1 surgical resections.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

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