Thesis topic proposal
Attila Miseta
The role of phosphoglucamutase in the therapeutic action of lithium


Institute: University of Pécs
clinical medicine
Doctoral School of Clinical Medicine

Thesis supervisor: Attila Miseta
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

The bipolar, (BP) or maniac depressive condition is second in occurrence among psychotic illnesses after the unipolar depression. It is particularly frequent in our country, but its occurrence is in excess of 1% in most other countries. According to our discovery the decreased activity of phosphoglucomutase (PGM) results in significantly elevated (6-9-fold) calcium storage in the presence of galactose in S. cerevisiae. The modification of calcium homeostasis and signaling affects the post-translational modifications of proteins in mammalian cells too. The mechanism may play significant role in the therapeutic action of lithium, and may present a clue to the phenomenon why some of the patients are lithium responders while others are non-responders.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

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