Thesis supervisor: István Kiss
Location of studies (in Hungarian): PTE ÁOK Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
In this PhD topic role of epigenetic factors is studied in relation to risk of cancer development, and as independent prognostic biomarkers. Role of different DNA-methylation patterns and microRNA expressions will be investigated (as potential markers of cancer risk) in human molecular epidemiological studies. With the help of clinical cooperation and on archive samples the same biomarkers will be determined from cancer tissues at diagnosis, and taking the course of the disease into account, the prognostic value of these biomarkers will be analyzed. The human studies will be supplemented with animal experiments, where the effect of potentially carcinogenic environmental/lifestyle factors will be studied on the change of methylation patterns and microRNA expressions, through several generations. These studies can shed light on the mechanisms how environmental effects may cause hereditary changes even without causing mutations.
Number of students who can be accepted: 1
Deadline for application: 2023-05-19
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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