Thesis supervisor: Zsuzsanna Faust
co-supervisor: Tamás Nagy
Location of studies (in Hungarian): PTE ÁOK Pés, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Malignant cells tend to have higher metabolic rate to meet the increased requirements of cell growth and division. Reverting to more primitive, anaerob metabolism is also frequently observed in cancer. The result is a significantly elevated glucose consumption. One of the consequences of increased carbohydrate metabolism is enhanced protein O-N-acetyl-glucosamine (O-GlcNAc) modification. 1-3% of the glucose entering the cells is metabolized through the hexosamine biosynthesis pathway (HBP). The end-product of HBP; UDP-N-acetyl-glucosamine is a direct substrate for a post-translational modification on Ser/Thr moieties. This O-GlcNAc modification is a reversible, dynamic process in the cytoplasm and the nuclei. O-GlcNAc is increasingly recognized as a regulatory mechanism for many intracellular processes including signal transduction, phosphorylation, transcritional activity or protein degradation.
Detecting and analysing O-GlcNAc modification in malignancies has a great potential for the better understanding of the underlying patho-physiological mechanisms. Even more importantly, it might provide a useful diagnostic tool for the detection, risk assessment and monitoring of malignant disorders. Thus our aim is to develop an analytical method applicable for the clinical laboratory and based on their O-GlcNAc levels, to characterize malignant hematologic disorders such as CLL and CML.
Number of students who can be accepted: 1
Deadline for application: 2023-05-19
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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