Thesis supervisor: Balázs Gasz
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Cardiac surgery is associated with activation of harmful events resulting in increased risk of postoperative complications. Aortic cross clamping causes myocardial ischaemia and reperfusion with cellular mechanisms of oxidative injury, deterioration of antioxidant batteries. Furthermore, cardiopulmonary bypass and surgical stress are known to trigger whole body inflammatory response which may lead to activation of leukocytes and endothelial initiating oxidants. These processes can exacerbate the effects of myocardial ischaemia-reperfusion. These unwanted processes can be eliminated by cellular activation of endogen adaptation. It has been evidenced that given protocol of ischaemic postconditioning and controlled reperfusion can reduce tissue damage following myocardial ischemia-reperfusion. These mechanisms are not well-investigated in patients receiving cardiac surgery. During our investigation it is aimed to evaluate the cellular and subcellular mechanisms of endogen adaptation in cardiac surgical patients, which may influence the risk of complications.
Students are invited to examine the cellular mechanisms of postconditioning in animal experiments, furthermore determine the effects of postconditioning and controlled reperfusion in cardiac surgical patients on blood and tissue samples.
Number of students who can be accepted: 1
Deadline for application: 2023-05-19
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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