Thesis topic proposal
Potential genetic background of ischaemia-reperfusion injury of myocardium in cardiac surgery


Institute: University of Pécs
clinical medicine
Doctoral School of Clinical Medicine

Thesis supervisor: Balázs Gasz
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Cardiac surgery is associated with activation of harmful events resulting in increased risk of postoperative complications. Aortic cross clamping causes myocardial ischaemia and reperfusion with cellular mechanisms of oxidative injury, deterioration of antioxidant batteries. Furthermore, cardiopulmonary bypass and surgical stress are known to trigger whole body inflammatory response which may lead to activation of leukocytes and endothelial initiating There are inter-individual differences between patients regarding susceptibility of damaging effects during and following cardiac surgery. Individual differences of antioxidant enzymes activity may exert influence on systemic inflammatory response and myocardial damage upon ischaemia-reperfusion. These differences can also control how the mechanisms at cellular level can be manifested clinically. Present PhD program is aimed to investigate the genetic polymorphisms of given antioxidant enzymes and proteins involved in endogen adaptation. Polymorphisms of these proteins are suggested to influence the severity of systemic inflammatory response and myocardial damage.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )