Thesis topic proposal
Analysis of biogenesis and communication of extracellular vesicles


Institute: University of Pécs
theoretical medicine
Doctoral School of Interdisciplinary Medical Sciences

Thesis supervisor: Tibor Rauch
Location of studies (in Hungarian): PTE ÁOK
Abbreviation of location of studies: ÁOK

Description of the research topic:

Cell-to-cell communication can take place in the form of phospholipid-enveloped extracellular vesicles (EVs). Proteins, miRNAs, and mRNAs involved in cell-to-cell communication are selectively packaged into the EVs. Different RNA species can directly or indirectly influence the gene expression pattern in acceptor cells and determine the direction of cellular differentiation. The aim of our study is to identify factors and mechanisms involved in the selective packaging (so-called sorting) of EV RNAs. We also investigate the molecular targets of the EV RNAs in the acceptor cells, and reveal how they affect the cellular course of the disease and the healing process.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

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