Thesis topic proposal
Szimonetta Lohner
The impact of clinical research results on preventive and therapeutic medical decisions


Institute: University of Pécs
theoretical medicine
Doctoral School of Interdisciplinary Medical Sciences

Thesis supervisor: Szimonetta Lohner
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Clinical trials are designed and conducted to help physicians make the most appropriate therapeutic decisions. However, in practice, this translation process is often biased.
Within the PhD theme, sources of bias are examined from a scientific perspective, with the aim of formulating practice-oriented responses on how to eliminate specific kinds of bias.
The theme includes, but is not restricted to the following questions: What impact do non-published or partially published trial data have on clinical decision-making? How are harms defined in clinical trials and how and to what extent does information on harm appear in scientific publications? How can the conflict of interest between industry and academia in designing, conducting, analyzing and publishing studies be resolved? How scientific information generated in Hungarian clinical trials is spreading as compared to trial results from other European countries and to what extent it gets incorporated into international professional guidelines? How can we deal with bias when conducting evidence summaries for clinicians? Is it enough to measure intermediate markers in order to make well-founded conclusions about the effectiveness of a therapy?

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )