Thesis topic proposal
Magnetic resonance imaging (MRI) and spectroscopic (MRS) study of various disease models in vitro, in situ and on small animals in vivo


Institute: University of Pécs
theoretical medicine
Doctoral School of Interdisciplinary Medical Sciences

Thesis supervisor: Zoltan Berente
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Nuclear magnetic resonance, due to its inherently advantageous properties, is especially suitable for noninvasive and nondestructive study of the living material (cells, tissues, intact living creatures). The method provides morphological, cellular (e.g. diffusion and perfusion) and molecular (e.g. metabolite concentrations) information practically simultaneously and in a spatially resolved manner. A further advantage of the method is that using non-radioactive isotope labelling it provides the localisation of the label not only among but also within the metabolites (i.e. which carbon atom(s) of a certain metabolite become(s) labelled). The planned studies are aimed at identifying in vivo detectable and quantifiable markers that indicate the extent and progression of the damages present in disease models. A further objective is monitoring these markers during experimental therapies (e.g. application of drug candidates) in order to characterise the efficacy of the therapy. The applicant will join the work of the MR lab in the Szentágothai Research Center of University of Pécs. The lab is already equipped with a Bruker Avance III 500 NMR spectrometer (11.7 T magnet) and during the year 2015 a 4.7 T small animal MRI instrument will be installed.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )