Thesis topic proposal
Development of stress-related disorders in a mouse model of Alzheimer's disease


Institute: University of Pécs
theoretical medicine
Doctoral School of Basic Medicine

Thesis supervisor: Dóra Zelena
Location of studies (in Hungarian): PTE ÁOK
Abbreviation of location of studies: ÁOK

Description of the research topic:

In a triple transgenic mouse model of Alzheimer’s disease, we plan to map the development of comorbid anxiety depression. According to the literature, disease-specific brain lesions appear in 6-month-old mice, so a comparison of 4- and 8-month-old animals is planned. In parallel with extensive behavioral analyzes, we also plan to monitor the development of stress hormone levels, as depression is particularly characterized by increased stress activity, which is not sensitive to negative feedback from the effector molecule (e.g. glucocorticoids).

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

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