Thesis supervisor: András Komócsi
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Pulmonary arterial hypertension (PAH) is a severe and currently incurable condition. The exact mechanisms leading to the pulmonary vasculature remodeling and the consequent right ventricular overload and insufficiency are still unclear. Intensive research for potential targets in the pathological mechanisms during the last decade resulted in a break-through of therapeutic modalities. However, in PAH cases even if the patient has received extensive combination therapies, disease may still progress. Altogether there is an unmet need for effective treatment interfering with the progression of the disease. Our aim is to investigate different rat models of PAH in order to explore the underlying cellular and molecular pathways and to evaluate the effects of existing and novel therapeutic approaches.