Thesis topic proposal
András Komócsi
Novel targets of medical treatment in pulmonary hypertension


Institute: University of Pécs
theoretical medicine
Doctoral School of Basic Medicine

Thesis supervisor: András Komócsi
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Pulmonary arterial hypertension (PAH) is a severe and currently incurable condition. The exact mechanisms leading to the pulmonary vasculature remodeling and the consequent right ventricular overload and insufficiency are still unclear. Intensive research for potential targets in the pathological mechanisms during the last decade resulted in a break-through of therapeutic modalities. However, in PAH cases even if the patient has received extensive combination therapies, disease may still progress. Altogether there is an unmet need for effective treatment interfering with the progression of the disease. Our aim is to investigate different rat models of PAH in order to explore the underlying cellular and molecular pathways and to evaluate the effects of existing and novel therapeutic approaches.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )