Thesis topic proposal
Hajnalka Ábrahám
Study of the link between pharmaceutical fever and febrile seizure reduction and the prevention of the development of hippocampal sclerosis


Institute: University of Pécs
clinical medicine
Doctoral School of Clinical Neurosciences

Thesis supervisor: Hajnalka Ábrahám
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsies, and based on earlier data, more than 70% of the patients have hippocampal sclerosis (HS). Frequently, HS is preceded by childhood complex febrile seizure (FS). Our aim is to investigate the structural and functional changes caused by FS and NSAIDs used for the fever reduction. Our examinations will be performed on animal models of FS, on organotypic hippocampal and neocortical slice and cell culture. In addition to the experiments, surgically removed cortical tissue of TLE patients with HS and with a history of FS will be examined. Those results obtained in experiments will be tested in the surgical tissue of the patients.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )