Thesis supervisor: Éva Szőke
Location of studies (in Hungarian): PTE ÁOK Szigeti u. 12. Abbreviation of location of studies: ÁOK
Description of the research topic:
Chronic persistent pain of different origin (inflammatory and degenerative joint diseases, cancer, neuropathy and migraine) are great health and social problems that decrease the quality of life of a large population. The treatment of neuropathic pain is still an unresolved problem, the presently available drug groups (anti-epileptics, opiates, anti-depressants, lidocaine) do not provide satisfactory relief in most cases. Transient Receptor Potential (TRP) cation channels as the TRP Vanilloid 1 (TRPV1) are nocisensors playing important role to trigger pain. TRPV1 serves as thermosensor and is suitable to be activated also by several exogenous and endogenous chemical ligands. Our aim was to investigate the gating of the TRPV1 receptor in sensory neurons, sensory nerve terminals or receptor-expressing cell line and its role in pain transmission in in vivo animal models.
Number of students who can be accepted: 1
Deadline for application: 2023-05-17
2024. IV. 17. ODT ülés Az ODT következő ülésére 2024. június 14-én, pénteken 10.00 órakor kerül sor a Semmelweis Egyetem Szenátusi termében (Bp. Üllői út 26. I. emelet).
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