Thesis topic proposal
Márta Balaskó
The role of central insulin in the regulation of energy balance in rats, according to age and nutritional state


Institute: University of Pécs
theoretical medicine
Doctoral School of Pharmacologycal and Pharmaceutical Sciences

Thesis supervisor: Márta Balaskó
co-supervisor: Szilvia Soós
Location of studies (in Hungarian): PTE ÁOK Pécs, Szigeti u. 12.
Abbreviation of location of studies: ÁOK

Description of the research topic:

In the CNS insulin is important in the regulation of energy balance and peripheral glucose metabolism. The central effects of insulin are anorexia, hypermetabolism, and it also suppresses glucose release from the liver. However, with aging and/or obesity insulin resistance may develop not only in the periphery, but also in the brain, what may contribute to the development of metabolic syndrome. Accordingly, rats of various age-groups will be given intracerebroventricular insulin injection or infusion to analyze the development of central resistance. Since the resistance may also depend on the nutritional state, the central insulin sensitivity is to be analyzed also in rats of similar ages but kept chronically on calorie restricted diet and in diet-induced obese rats. Glucose tolerance test will be performed in all cases.

Number of students who can be accepted: 1

Deadline for application: 2023-05-19

All rights reserved © 2007, Hungarian Doctoral Council. Doctoral Council registration number at commissioner for data protection: 02003/0001. Program version: 2.2358 ( 2017. X. 31. )